Natural killer cell deficiency.

Impaired cytotoxicity associated with defective natural killer cell differentiation in myelodysplastic syndromes.

Natural killer cells are well known to mediate anti-leukemic responses in myeloid leukemia but their role in myelodysplastic syndromes is not well understood. Here, in a cohort of newly diagnosed patients (n=75), widespread structural and functional natural killer cell defects were identified. One subgroup of patients (13%) had a selective deficiency of peripheral natural killer cells (count <1...

Exploring the relationship between natural killer cells and cutaneous squamous cell carcinoma development

cSCC: cutaneous squamous cell carcinoma FNKD: functional natural killer cell deficiency HPV: human papillomavirus KIR: killer cell immunoglobulin-like receptor MHC: major histocompatibility complex NK: natural killer INTRODUCTION There are many conditions associated with the formation of numerous cutaneous squamous cell carcinomas (cSCCs), including, among others, xeroderma pigmentosum, epiderm...

Natural Killer Cell Cytotoxicity Against SKOV3 after HLA-G Downregulation by shRNA

Background: HLA-G is a nonclassical HLA class I molecule which, when elevated in tumor cells, is one of the main factors involved in tumor evasion of immune responses including NK and T cells. Objective: To evaluate the effect of HLA-G downregulation on NK cell cytotoxicity in tumor cell lines. Methods: The expression level of HLA-G was measured by real-time PCR and flowcytometry after transfec...

This is an author produced version of Natural killer (NK) cell function in paroxysmal nocturnal hemoglobinuria: A deficiency of NK cells, but not an NK cell deficiency. White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/84575/

Altered chemotactic response to CXCL12 in patients carrying GATA2 mutations.

GATA2 deficiency-formerly described as MonoMAC syndrome; dendritic cells, monocytes, B cells, and natural killer cell deficiency; familial myelodysplastic syndrome/acute myeloid leukemia; or Emberger syndrome-encompasses a range of hematologic and nonhematologic anomalies, mainly characterized by monocytopenia, B lymphopenia, natural killer cell cytopenia, neutropenia, immunodeficiency, and a h...

Natural killer cell-mediated immune deficiency or compromise in patients with portopulmonary hypertension

Portopulmonary hypertension (POPH) is a form of pulmonary arterial hypertension (PAH) in the setting of portal hypertension, and is associated with a poor prognosis [1]. The underling etiological cause of POPH is poorly understood [1]. Previously we have reported T cell-mediated immune deficiency or compromise in patients with chronic thromboembol-ic pulmonary hypertension (CTEPH), idiopathic p...